Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

The content of proteoglycans (PGs) is low in the extracellular matrix (ECM) of vascular
tissue, but increases dramatically in all phases of vascular disease. Early studies …

Retention of apo B-100 lipoproteins, low density lipoprotein (LDL) and probably lipoprotein
(a), Lp (a), by intima proteoglycans (PGs) appears to increase the residence time needed for …

The subendothelial aggregation and retention of low density lipoprotein (LDL) are key
events in atherogenesis, but the mechanisms in vivo are not known. Previous studies have …

Initiation of atherosclerosis is characterized by accumulation of aggregates of small lipid
droplets and vesicles in the extracellular matrix of the arterial intima. The droplets and …

Pentikäinen MO, Öörni K, Ala‐Korpela M, Kovanen PT (Wihuri Research Institute, Helsinki,
Finland). Modified LDL–trigger of atherosclerosis and inflammation in the arterial intima …

Secretory phospholipase A2 (PLA2) can be proatherogenic both in the circulation and in the
arterial wall. In blood plasma, PLA2 can modify the circulating lipoproteins and so induce …

Objective—We investigated the potential role of ADAMTS-1 (a disintegrin and
metalloprotease with thrombospondin motif type I) in atherogenesis. Methods and Results …

The hypothesis of a causal relation between disturbances of apoB lipoprotein metabolism
and atherosclerosis is consistent with results from recent intervention studies with drugs that …

Mammalian secreted phospholipases A 2 (sPLA2s) comprise a group of at least eight
enzymes, including the recently identified group X sPLA2. A bacterial expression system …