Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …

Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …

Little is known about the genetic architecture of traits affecting educational attainment other
than cognitive ability. We used genomic structural equation modeling and prior genome …

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …

Local genetic correlation quantifies the genetic similarity of complex traits in specific
genomic regions. However, accurate estimation of local genetic correlation remains …

Background Diverse behaviour problems in childhood correlate phenotypically, suggesting
a general dimension of psychopathology that has been called the p factor. The shared …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …