The resolution of the inflammatory response is highly regulated by the timely biosynthesis of
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …

The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive
products produced by the action of the lipoxygenase family of enzymes. The LT receptors …

The lung is ventilated by thousand liters of air per day. Inevitably, the respiratory system
comes into contact with airborne microbial compounds, most of them harmless …

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …

In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and
inflammation. However, cilia beating features in a CF altered environment, consisting of …

Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is
critical to health that these responses be controlled to prevent tissue damage and the …

Inflammation is an a physiological response instead an essential response of the organism
to injury and its adequate resolution is essential to restore homeostasis. However, defective …

Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance,
persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the …

The pulmonary epithelium is divided into upper, lower, and alveolar (or small) airway
epithelia and acts as the mechanical and immunological barrier between the external …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a …