Genetics of rheumatoid arthritis

L Padyukov - Seminars in immunopathology, 2022 - Springer
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

M Volkov, KA van Schie… - Immunological …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …

[HTML][HTML] MSU crystal deposition contributes to inflammation and immune responses in gout remission

H Gu, H Yu, L Qin, H Yu, Y Song, G Chen, D Zhao… - Cell Reports, 2023 - cell.com
As a prominent feature of gout, monosodium urate (MSU) crystal deposition induces gout
flares, but its impact on immune inflammation in gout remission remains unclear. Using …

[HTML][HTML] Interleukins and rheumatoid arthritis: bi-directional Mendelian randomization investigation

S Yuan, X Li, A Lin, SC Larsson - Seminars in Arthritis and Rheumatism, 2022 - Elsevier
Objectives To assess the causality of the associations between interleukins (ILs) and
rheumatoid arthritis (RA) using Mendelian randomization (MR) design. Methods Genetic …

[HTML][HTML] Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases

Y Shi, H Qian, P Rao, D Mu, Y Liu, G Liu… - Acta Pharmaceutica Sinica …, 2022 - Elsevier
Autoimmune or infectious diseases often instigate the undesirable damages to tissues or
organs to trigger immune-related diseases, which involve plenty of immune cells, pathogens …

Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis

CT Deakin, J Bowes, LG Rider, FW Miller… - Human molecular …, 2022 - academic.oup.com
Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease and the most
common idiopathic inflammatory myopathy of children. JDM and adult-onset …

[HTML][HTML] HLA-DQA1 and DQB1 alleles are associated with acitretin response in patients with psoriasis

X Zhou, Y He, Y Kuang, W Chen, W Zhu - Frontiers in Bioscience …, 2022 - imrpress.com
Background: Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although
the pathogenesis of psoriasis is unclear, genetic susceptibility, such as HLA-C* 06: 02, is …

Rheumatoid arthritis: pathogenesis and therapeutic advances

Y Gao, Y Zhang, X Liu - MedComm, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved
synovial inflammation for tissues‐destructive consequence, which remains one of significant …

MicroRNA variants and HLA-miRNA interactions are novel rheumatoid arthritis susceptibility factors

S Guo, Y Jin, J Zhou, Q Zhu, T Jiang, Y Bian… - Frontiers in …, 2021 - frontiersin.org
Genome-wide association studies have identified> 100 genetic risk factors for rheumatoid
arthritis. However, the reported genetic variants could only explain less than 40% heritability …

[HTML][HTML] Causal risk and protective factors in rheumatoid arthritis: A genetic update

M Arleevskaya, E Takha, S Petrov, G Kazarian… - Journal of Translational …, 2021 - Elsevier
The characterization of risk and protective factors in complex diseases such as rheumatoid
arthritis (RA) has evolved from epidemiological studies, which test association, to the use of …