Comprehensive review on the Bis–heterocyclic compounds and their anticancer efficacy

MHA Al-Jumaili, AA Hamad, HE Hashem… - Journal of Molecular …, 2023 - Elsevier
Heterocyclic compounds are one of the largest family of organic compounds with broad
range of applications in medicinal chemistry and agrochemicals product. Bis-heterocycle …

Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile

SK Ramadan, AK El-Ziaty… - Synthetic Communications, 2021 - Taylor & Francis
A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …

New isoxazoline‐linked 1, 3, 4‐thiadiazole derivatives: Synthesis, antiproliferative activity, molecular docking, molecular dynamics and DFT

Y Laamari, MT Muhammed, A Irfan, A Oubella… - Journal of Molecular …, 2025 - Elsevier
Utilising (D)-Limonene as the starting material, this study reports the efficient synthesis of
two series of isoxazoline derivatives linked with the 1, 3, 4-thiadiazole moiety. The …

Cross-linked chitosan/multi-walled carbon nanotubes composite as ecofriendly biocatalyst for synthesis of some novel benzil bis-thiazoles

LA Alshabanah, SM Gomha, LA Al-Mutabagani… - Polymers, 2021 - mdpi.com
Aminohydrazide cross-linked chitosan (CLCS) and its MWCNTs (CLCS/MWCNTs) were
formulated and utilized as a potent ecofriendly basic heterogeneous biocatalyst under …

3-Aryl/hetaryl-2-cyanoacryloyl chlorides: Synthesis and reactions with binucleophiles targeting heterocycles

EAE El-Helw, AK El-Ziaty - Egyptian Journal of Chemistry, 2022 - journals.ekb.eg
In this review, we reported the synthetic method used to construct thirteen derivatives of 3-
aryl/heteryl-2-cyanoacryloyl chloride followed by a focused survey on their spectral data and …

Synthesis and In Silico Study of Some New bis-[1,3,4]thiadiazolimines and bis-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease

SM Gomha, SM Riyadh, MH Abdellattif… - Current Issues in …, 2022 - mdpi.com
A novel series of bis-[1, 3, 4] thiadiazolimines, and bis-thiazolimines, with alkyl linker, were
synthesized through general routes from cyclization of 1, 1′-(hexane-1, 6-diyl) bis (3 …

Antimicrobial and Molecular Docking Studies of 1,3,4-Thiadiazole Tethered Sulfa-Azo Derivatives via Hydrazono-Methyl Bridge

MS Abdel-Aziz, AA Sediek… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Abstract A new series of 1, 3, 4-thiadiazole linked to sulfa-azo derivatives via hydrazono-
methyl bridge were synthesized via the reaction of methyl ((E)-(sulfa-derivatives) diazenyl) …

[HTML][HTML] Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates

MA Said, SM Riyadh, NS Al-Kaff, AA Nayl… - Arabian Journal of …, 2022 - Elsevier
A novel series of bis-(Abdelhamid et al., 2017, Banerjee et al., 2018, Bharanidharan et al.,
2022) thiadiazoles was synthesized from the reaction of precursor dimethyl 2, 2′-(1, 2 …

Synthesis of 1, 3, 4-thiadiazole derivatives using hydrazonoyl bromide: Molecular docking and computational studies

YH Zaki, AO Abdelhamid, AR Sayed… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Alkyl phenylcarbamodithioates were reacted with hydrazonoyl bromide 1a, b in ethanol
containing a catalytic amount of triethylamine solution to afford and 1, 3, 4-thiadiazole …

Eco-synthesis route: Developing bis-hydrazono [1, 2, 4]-thiadiazoles via a green synthetic approach with calcium oxide-chitosan nanocomposite

NA Alshaye, SM Riyadh, KD Khalil, NS Alharbi… - International Journal of …, 2024 - Elsevier
Modern environmental organic chemistry is focused on developing cost-efficient, versatile,
environmentally acceptable catalytic chemicals that are also highly effective. Herein, hybrid …