Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Neutrophils accumulate in solid tumors, and their abundance correlates with poor prognosis.
Neutrophils are not homogeneous, however, and could play different roles in cancer …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally
diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain …

The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …

Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …

APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds
ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non …

Neutrophils are increasingly recognized as key players in the tumor immune response and
are associated with poor clinical outcomes. Despite recent advances characterizing the …