Systemic sclerosis (SSc) is a connective tissue disease clinically characterized by different
degrees of skin fibrosis and visceral organ involvement (17, 19, 22). The etiology of SSc …

The complement system is a component of the innate immune system. Its main function was
initially believed to be limited to the recognition and elimination of pathogens through direct …

Objectives Systemic sclerosis (SSc) is a rare disease requiring multicentre collaboration to
reveal comprehensive details of disease-related causes for morbidity and mortality. Methods …

Covering both the scientific basis of rheumatology and practical, clinical information for
rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast …

Background Validity of European Scleroderma Study Group (EScSG) activity indexes
currently used to assess disease activity in systemic sclerosis (SSc) has been criticised …

Abstract Background Systemic sclerosis (SSc) is characterised by multi-organ tissue fibrosis
including the myocardium. Diffuse myocardial fibrosis can be detected non-invasively by T1 …

Background. Microvascular lesions are a predominant feature in systemic sclerosis (SSc)
and seem to play a central pathogenetic role. Recently, we graded scleroderma …

Systemic sclerosis (SSc) is a family of diseases with a wide spectrum of clinical and
laboratory manifestations [1]. Its natural history is most easily understood by dividing the two …

Objectives: The safety and potential efficacy of rituximab was examined in diffuse cutaneous
systemic sclerosis (dc-SSc). Methods: A 24 week open-label study in which eight patients …

Objective To investigate correlations between serum levels of topoisomerase I–specific
antibody (anti–topo I) and clinical features of systemic sclerosis (SSc), including disease …