The topic of ceramidases has experienced an enormous boost during the last few years.
Ceramidases catalyze the degradation of ceramide to sphingosine and fatty acids …

Extensive research conducted in the last three decades has identified the roles for the main
bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate …

Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes in
human physiology. The central metabolite is ceramide, a pro‐apoptotic lipid catabolized by …

Ceramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from
endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step of …

Real‐time monitoring of acid sphingomyelinase (ASM) activity is crucial for investigating its
role in lipid‐mediated signaling processes. In this study, we synthesized fluorescent …

Neutral ceramidase (nCDase) catalyzes conversion of the apoptosis-associated lipid
ceramide to sphingosine, the precursor for the proliferative factor sphingosine-1-phosphate …

Background: Chlamydia trachomatis is an intracellular pathogen that requires different
nutrients, including sphingolipids, for survival. Components for the transport and …

Ceramides (Cer) are bioactive sphingolipids that have been proposed as potential disease
biomarkers since they are involved in several cellular stress responses, including apoptosis …

Chlamydia trachomatis is a medically important human pathogen causing different diseases,
including trachoma, the leading cause of preventable blindness in developing countries …

Molecular bioimaging of enzyme activity is rapidly emerging as a powerful strategy for
accurate disease diagnostics. This work aims to prove that bioimaging of enzyme activity in …