Harnessing genomic information for livestock improvement

M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

Genetics and genomics of reproductive performance in dairy and beef cattle

DP Berry, E Wall, JE Pryce - animal, 2014 - cambridge.org
Excellent reproductive performance in both males and females is fundamental to profitable
dairy and beef production systems. In this review we undertook a meta-analysis of genetic …

Invited review: overview of new traits and phenotyping strategies in dairy cattle with a focus on functional traits

C Egger-Danner, JB Cole, JE Pryce, N Gengler… - Animal, 2015 - cambridge.org
For several decades, breeding goals in dairy cattle focussed on increased milk production.
However, many functional traits have negative genetic correlations with milk yield, and …

A comprehensive biomedical variant catalogue based on whole genome sequences of 582 dogs and eight wolves

V Jagannathan, C Drögemüller, T Leeb… - Animal …, 2019 - Wiley Online Library
The domestic dog serves as an excellent model to investigate the genetic basis of disease.
More than 400 heritable traits analogous to human diseases have been described in dogs …

Inbreeding depression in livestock species: review and meta‐analysis

G Leroy - Animal genetics, 2014 - Wiley Online Library
Inbreeding, by virtue of its consequence on traits of interest, is a topic of major interest for
geneticists and animal breeders. Based on meta‐analysis conducted on 57 studies and …

Identification of genomic regions associated with inbreeding depression in Holstein and Jersey dairy cattle

JE Pryce, M Haile-Mariam, ME Goddard… - Genetics Selection …, 2014 - Springer
Background Inbreeding reduces the fitness of individuals by increasing the frequency of
homozygous deleterious recessive alleles. Some insight into the genetic architecture of …

Next‐generation metrics for monitoring genetic erosion within populations of conservation concern

G Leroy, EL Carroll, MW Bruford… - Evolutionary …, 2018 - Wiley Online Library
Genetic erosion is a major threat to biodiversity because it can reduce fitness and ultimately
contribute to the extinction of populations. Here, we explore the use of quantitative metrics to …

A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: additional evidence for the common …

NK Kadri, G Sahana, C Charlier, T Iso-Touru… - PLoS …, 2014 - journals.plos.org
In dairy cattle, the widespread use of artificial insemination has resulted in increased
selection intensity, which has led to spectacular increase in productivity. However, cow …

[HTML][HTML] Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility

JB Cole, DJ Null, PM VanRaden - Journal of dairy science, 2016 - Elsevier
Phenotypes from the August 2015 US national genetic evaluation were used to compute
phenotypic effects of 18 recessive haplotypes in Ayrshire (n= 1), Brown Swiss (n= 5) …

[HTML][HTML] Identification of a nonsense mutation in APAF1 that is likely causal for a decrease in reproductive efficiency in Holstein dairy cattle

HA Adams, TS Sonstegard, PM VanRaden, DJ Null… - Journal of dairy …, 2016 - Elsevier
The HH1 haplotype on chromosome 5 is associated with a reduced conception rate and a
deficit of homozygotes at the population level in Holstein cattle. The source HH1 haplotype …