The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

Psoriasis is an autoimmune inflammatory skin disease. In the past several decades,
phototherapy has been widely used to treat stable psoriatic lesions, including trunk, scalp …

Psoriasis is a common and chronic inflammatory skin disease in which T cells play a key
role. Effective treatment heals the skin without scarring, but typically psoriasis recurs in …

Immune system acts as a host defensive mechanism protecting against attacking pathogens
and transformed cells, including cancer cells. Th17 cells are a specific subset of T helper …

T helper 17 (Th17) cells play a complex and controversial role in tumor immunity and have
been found to exhibit a fluctuating identity within the context of cancer. The recent …

The recent worldwide rise in idiopathic immune and inflammatory diseases such as multiple
sclerosis (MS) and inflammatory bowel diseases (IBD) has been linked to Western society …

Psoriasis is a complex disease triggered by genetic, immunologic, and environmental
stimuli. Many genes have been linked to psoriasis, like the psoriasis susceptibility genes …

Psoriasis is a skin disease where various cytokines play a detrimental role, yet our
understanding of the disease is still limited. TNF is a validated drug target in psoriasis and …

UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …

Background: Phototherapy is one of the most efficacious treatment options for psoriasis.
New, emerging studies are beginning to define the biologic mechanisms by which …