Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

Since its discovery twenty-five years ago, the fat-derived hormone leptin has provided a
revolutionary framework for studying the physiological role of adipose tissue as an …

Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in
obesity. Leptin exerts many different actions on various tissues and systems, including …

Abstract Background and Aims Hepatocellular carcinoma (HCC) is the third leading cause of
cancer‐related mortality. Risk factors for developing HCC include viral hepatitis, alcohol and …

Leptin is an obesity-associated adipokine that is known to regulate energy metabolism and
reproduction and to control appetite via the leptin receptor. Recent work has identified …

Obesity is a chronic disease caused by the accumulation of excessive adipose tissue. This
disorder is characterized by chronic low‑grade inflammation, which promotes the release of …

Background As the obesity epidemic worsens, the prevalence of fatty liver disease has
increased. However, minimal data exist on the impact of combined fatty liver and metabolic …

Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to
fibrosis and, finally, into cancer. Many etiological factors, including hepatitis B virus X …

Leptin is a peptide hormone that has been characterized as the ligand of leptin receptor
(LEPR). The observation of leptin secretion and leptin receptor expression beyond the …