Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron
degeneration. Mutations in more than 50 human genes cause diverse types of motor neuron …

Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of
neurological disorders characterized by a progressive, age-dependent decline in neuronal …

Introduction The accumulation of insoluble proteins within neurons and glia cells is a
pathological hallmark of several neurodegenerative diseases. Abnormal aggregation of the …

Formation of new neurons in the adult brain takes place in the subventricular zone and in
the subgranule layer of the dentate gyrus throughout life. Neurogenesis is thought to play a …

Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated
protein) represent pathological hallmarks of Alzheimer's disease (AD) and other …

Epilepsy is a group of chronic neurological disorders characterized by recurrent,
spontaneous, and unpredictable seizures. It is one of the most common neurological …

We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically
beneficial in tauopathies by functionally substituting for the MT-binding protein tau, which is …

Abstract Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the
CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's …

Background Tubulin is a major substrate of the cytoplasmic class II histone deacetylase
HDAC6. Inhibition of HDAC6 results in higher levels of acetylated tubulin and enhanced …

Plaques composed of amyloid β (Aβ) have been found within days following brain trauma in
humans, similar to the hallmark plaque pathology of Alzheimer's disease (AD). Here, we …