FBXW7: a critical tumor suppressor of human cancers
The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes,
such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer …
such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer …
Roles of F-box proteins in cancer
F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …
A phase II trial of the aurora kinase a inhibitor alisertib for patients with castration-resistant and neuroendocrine prostate cancer: efficacy and biomarkers
H Beltran, C Oromendia, DC Danila… - Clinical Cancer …, 2019 - AACR
Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate
cancer that may develop de novo or as a mechanism of treatment resistance. N-myc is …
cancer that may develop de novo or as a mechanism of treatment resistance. N-myc is …
Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities
RJ Davis, M Welcker, BE Clurman - Cancer cell, 2014 - cell.com
Tumor suppressors with widespread impact on carcinogenesis control broad spectra of
oncogenic pathways. Protein degradation is an emerging mechanism by which tumor …
oncogenic pathways. Protein degradation is an emerging mechanism by which tumor …
Aurora A kinase (AURKA) in normal and pathological cell division
Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …
Recent insight into the role of FBXW7 as a tumor suppressor
K Yumimoto, KI Nakayama - Seminars in cancer biology, 2020 - Elsevier
FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but
whether Aurora-A is also involved in metabolic reprogramming-mediated cancer …
whether Aurora-A is also involved in metabolic reprogramming-mediated cancer …
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma
VL Cannataro, SG Gaffney, T Sasaki, N Issaeva… - Oncogene, 2019 - nature.com
Recent studies have revealed the mutational signatures underlying the somatic evolution of
cancer, and the prevalences of associated somatic genetic variants. Here we estimate the …
cancer, and the prevalences of associated somatic genetic variants. Here we estimate the …
eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
The translation elongation factor eEF1A promotes protein synthesis. Its methylation by
METTL13 increases its activity, supporting tumor growth. However, in some cancers, a high …
METTL13 increases its activity, supporting tumor growth. However, in some cancers, a high …
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer
The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle
assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the …
assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the …