Except in rare cases, the stomach can withstand exposure to highly concentrated
hydrochloric acid, refluxed bile salts, alcohol, and foodstuffs with a wide range of …

Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14. 99.1) catalyzes the first two
steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 …

TPA, tetradecanoyl phorbol acetate. immediately in acute inflammation prior to the
recruitment of leukocytes. As immune cells infiltrate the tissues, further increases in …

In the past 100 years aspirin has demonstrated its value as an analgesic, anti-inflammatory,
and antithrombotic agent. However, by 1938, it was clear that aspirin was gastrotoxic. Non …

Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by
blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin …

Background & Aims: Selective cyclooxygenase (COX)-2 inhibitors produce less gastric
damage than conventional nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting that …

Monocyte chemoattractant protein (MCP)–3 is inactivated upon cleavage by the matrix
metalloproteinase (MMP) gelatinase A (MMP-2). We investigated the susceptibility to …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in
inflammatory diseases, since they are effective in management of pain, fever, redness …

Despite the molecular and histological similarities between fetal bone development and
fracture healing, inflammation is an early phase of fracture healing that does not occur …

Address correspondence to: William L. Smith, 513 Biochemistry Building, Department of
Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan …