And then there was light: perspectives of optogenetics for deep brain stimulation and neuromodulation

J Delbeke, L Hoffman, K Mols, D Braeken… - Frontiers in …, 2017 - frontiersin.org
Deep Brain Stimulation (DBS) has evolved into a well-accepted add-on treatment for
patients with severe Parkinsons disease as well as for other chronic neurological conditions …

[HTML][HTML] Emerging trends in the development of flexible optrode arrays for electrophysiology

RM Almasri, F Ladouceur, D Mawad… - APL …, 2023 - pubs.aip.org
Optical-electrode (optrode) arrays use light to modulate excitable biological tissues and/or
transduce bioelectrical signals into the optical domain. Light offers several advantages over …

Activity of retinal neurons can be modulated by tunable near-infrared nanoparticle sensors

JM Begeng, W Tong, B Rosal, M Ibbotson… - ACS …, 2023 - ACS Publications
The vision of patients rendered blind by photoreceptor degeneration can be partially
restored by exogenous stimulation of surviving retinal ganglion cells (RGCs). Whereas …

Thermoplasmonic optical fiber for localized neural stimulation

H Kang, W Hong, Y An, S Yoo, HJ Kwon, Y Nam - ACS nano, 2020 - ACS Publications
Thermoplasmonic effect-based neural stimulation has been suggested as an alternative
optical neural stimulation technology without genetic modification. Integration of near …

Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice

ÁC Horváth, S Borbély, ÖC Boros… - Microsystems & …, 2020 - nature.com
Brain is one of the most temperature sensitive organs. Besides the fundamental role of
temperature in cellular metabolism, thermal response of neuronal populations is also …

Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study

M Ganguly, JB Ford, J Zhuo, MT McPheeters… - …, 2019 - spiedigitallibrary.org
Thermal block of unmyelinated axons may serve as a modality for control, suggesting a
means for providing therapies for pain. Computational modeling predicted that potassium …

Spike frequency–dependent inhibition and excitation of neural activity by high-frequency ultrasound

ML Prieto, K Firouzi, BT Khuri-Yakub… - Journal of General …, 2020 - rupress.org
Ultrasound can modulate action potential firing in vivo and in vitro, but the mechanistic basis
of this phenomenon is not well understood. To address this problem, we used patch-clamp …

Histological and electrophysiological evidence on the safe operation of a sharp-tip multimodal optrode during infrared neuromodulation of the rat cortex

ÁC Horváth, S Borbély, F Mihók, P Fürjes, P Barthó… - Scientific Reports, 2022 - nature.com
Infrared neuromodulation is an emerging technology in neuroscience that exploits the
inherent thermal sensitivity of neurons to excite or inhibit cellular activity. Since there is …

Inhibition of cortical neural networks using infrared laser

Q Xia, T Nyberg - Journal of biophotonics, 2019 - Wiley Online Library
The aim of the present study is to optimize parameters for inhibiting neuronal activity safely
and investigating thermal inhibition of rat cortex neural networks in vitro by continuous …

Pulsed infrared releases Ca2+ from the endoplasmic reticulum of cultured spiral ganglion neurons

JN Barrett, S Rincon, J Singh… - Journal of …, 2018 - journals.physiology.org
Inner ear spiral ganglion neurons were cultured from day 4 postnatal mice and loaded with a
fluorescent Ca2+ indicator (fluo-4,-5F, or-5N). Pulses of infrared radiation (IR; 1,863 nm, 200 …