Cefiderocol appears promising, as it can overcome most β-lactam resistance mechanisms
(including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon …

Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of
serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β …

Background Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability
toward β-lactamases, including carbapenemases, achieved by combining structural …

The impact of broad-spectrum β-lactamases on the susceptibility to novel β-lactamase/β-
lactamase inhibitor combinations was evaluated both in Pseudomonas aeruginosa and …

Objectives To evaluate the in vitro activity of aztreonam in combination with novel β-
lactamase inhibitors, namely avibactam, nacubactam, taniborbactam and zidebactam …

Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a
global level during the last decades and represent an everyday challenge, especially for the …

Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat
(DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas …

Objectives To evaluate the performance of commercially available tests to determine the
susceptibility of multidrug-resistant (MDR) clinical Pseudomonas aeruginosa strains to …

Objectives To analyse the dynamics and mechanisms of stepwise resistance development
to cefiderocol in Pseudomonas aeruginosa. Methods Cefiderocol resistance evolution was …

Scope Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen considered one of
the paradigms of antimicrobial resistance, is among the main causes of hospital-acquired …