Staphylococcus aureus has been an exceptionally successful pathogen, which is still
relevant in modern age-medicine due to its adaptability and tenacity. This bacterium may be …

The treatment of bacterial infections is increasingly complicated by the ability of bacteria to
develop resistance to antimicrobial agents. Antimicrobial agents are often categorized …

Background Bacterial bloodstream infection is a common cause of morbidity and mortality in
sub-Saharan Africa, yet few facilities are able to maintain long-term surveillance. The Malawi …

Serious infections caused by bacteria that have become resistant to commonly used
antibiotics have become a major global healthcare problem in the 21st century. They not …

The emergence and spread of resistance in Enterobacteriaceae are complicating the
treatment of serious nosocomial infections and threatening to create species resistant to all …

Bacterial infections are a frequent cause of hospitalization, and nosocomial infections are an
increasingly common condition, particularly within the acute/critical care setting. Infection …

Pharmacodynamics (PDs) deals with the relationship between measures of drug exposure
and the antimicrobial effect. During the antibiotic era, interest in PDs has always been …

Abstract β-lactams have a long history in the treatment of infectious diseases, though their
use has been and continues to be confounded by the development of resistance in target …

We identified four bla KPC-3 mutations in ceftazidime-avibactam-resistant clinical Klebsiella
pneumoniae isolates, corresponding to D179Y, T243M, D179Y/T243M, and EL165-166 …

Background and Objective: Urinary tract infections (UTIs) are common in human medicine,
affecting large patient populations worldwide. The principal cause of UTIs is uropathogenic …