Eukaryotic cell cycle transitions are driven by E3 ubiquitin ligases that catalyze the
ubiquitylation and destruction of specific protein targets. For example, the anaphase …

Proper control of DNA replication is critical to ensure genomic integrity during cell
proliferation. In addition, differential regulation of the DNA replication program during …

The cell cycle in pluripotent stem cells is notable for the brevity of the G1 phase, permitting
rapid proliferation and reducing the duration of differentiation signal sensitivity associated …

A versatile division of apicomplexan parasites and a dearth of conserved regulators have
hindered the progress of apicomplexan cell cycle studies. While most apicomplexans divide …

To prevent re-replication of DNA in a single cell cycle, the licensing of replication origins by
Mcm2-7 is prevented during S and G2 phases. Animal cells achieve this by cell-cycle …

Abstract Development of multicellular organisms relies upon the coordinated regulation of
cellular differentiation and proliferation. Growing evidence suggests that some molecular …

Hedgehog (Hh) transduces signals by promoting cell surface accumulation and activation of
the G-protein-coupled receptor (GPCR)-family protein Smoothened (Smo) in Drosophila, but …

Polyploidy is an integral part of development and is associated with cellular stress, aging,
and pathological conditions. The endocycle, comprised of successive rounds of G and S …

Dosage-sensitive modifier screening is a powerful tool for linking genes to biological
processes. Use of chromosomal deletions permits sampling the effects of removing groups …

Cdt1 plays a critical role in DNA replication regulation by controlling licensing. In Metazoa,
Cdt1 is regulated by CRL4Cdt2-mediated ubiquitylation, which is triggered by DNA binding …