Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Iron deficiency anaemia is a Worldwide Public Health problem and the fortification of food
with iron is the most cost-effective prevention strategy. The correct combination of iron form …

Iron deficiency is a common condition increasingly diagnosed and treated by
gastroenterologists. The most common presentation of iron deficiency is anaemia; however …

BACKGROUND The peptide hormone hepcidin plays a central role in regulating dietary iron
absorption and body iron distribution. Many human diseases are associated with alterations …

Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis
of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder
resulting from genetic and environmental factors. Hyperferritinemia has been associated …

Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the
TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease …

Hepcidin is a liver-derived hormone with a key role in iron homeostasis. In addition to iron, it
is regulated by inflammation and hypoxia, although mechanisms of hypoxic regulation …

During recent years, our understanding of the pathogenesis of inherited microcytic anemias
has gained from the identification of several genes and proteins involved in systemic and …

Iron is an essential metal for many biologic processes in mammals. Its primary role is to bind
oxygen in the heme moiety of hemoglobin. Iron also plays a central role in the enzymatic …