Diabetes associated cell stress and dysfunction: role of mitochondrial and non‐mitochondrial ROS production and activity

P Newsholme, EP Haber, SM Hirabara… - The Journal of …, 2007 - Wiley Online Library
It is now widely accepted, given the current weight of experimental evidence, that reactive
oxygen species (ROS) contribute to cell and tissue dysfunction and damage caused by …

Glycerolipid metabolism and signaling in health and disease

M Prentki, SRM Madiraju - Endocrine reviews, 2008 - academic.oup.com
Maintenance of body temperature is achieved partly by modulating lipolysis by a network of
complex regulatory mechanisms. Lipolysis is an integral part of the glycerolipid/free fatty …

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

I Samudio, R Harmancey, M Fiegl… - The Journal of …, 2010 - Am Soc Clin Investig
The traditional view is that cancer cells predominately produce ATP by glycolysis, rather
than by oxidation of energy-providing substrates. Mitochondrial uncoupling—the continuing …

Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis–there is nothing more practical than a good theory

H BayIr, VE Kagan - Critical care, 2008 - Springer
Apoptosis contributes to cell death in common intensive care unit disorders such as
traumatic brain injury and sepsis. Recent evidence suggests that this form of cell death is …

[HTML][HTML] Emerging targets and treatments for sarcopenia: a narrative review

S Cacciatore, R Calvani, I Esposito, C Massaro… - Nutrients, 2024 - pmc.ncbi.nlm.nih.gov
Background: Sarcopenia is characterized by the progressive loss of skeletal muscle mass,
strength, and function, significantly impacting overall health and quality of life in older adults …

Mitochondrial biology in cancer stem cells

R Loureiro, KA Mesquita, S Magalhães-Novais… - Seminars in cancer …, 2017 - Elsevier
Cancer stem cells (CSCs) have been suggested to be responsible for tumor re-growth and
relapse. Physiological and morphological knowledge of CSCs may be essential for the …

p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid …

H Nakamura, S Matoba, E Iwai-Kanai… - Circulation: Heart …, 2012 - Am Heart Assoc
Background—Diabetic cardiomyopathy is characterized by energetic dysregulation caused
by glucotoxicity, lipotoxicity, and mitochondrial alterations. p53 and its downstream …

Changes of glycogen content in liver, skeletal muscle, and heart from fasted rats

E Kokubun, SM Hirabara, J Fiamoncini… - … biochemistry and its …, 2009 - Wiley Online Library
Glycogen content of white and red skeletal muscles, cardiac muscle, and liver was
investigated in conditions where changes in plasma levels of non‐esterified fatty acids …

Tissue adaptation to metabolic stress: insights from SUMOylation

H Xie, X Liu, S Li, M Wang, Y Li, T Chen, L Li… - Frontiers in …, 2024 - frontiersin.org
Post-translational modification (PTM) plays a crucial role in adaptation of mammals to
environmental changes, enabling them to survive in stressful situations. One such PTM is …

Glutamine supplementation prevents exercise‐induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression

CJ Lagranha, SM Hirabara, R Curi… - Cell Biochemistry and …, 2007 - Wiley Online Library
We have previously shown that a single session of exercise induces DNA fragmentation,
mitochondrial membrane depolarization, increases expression of pro‐apoptotic genes (bax …