Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Doublets are prevalent in single-cell sequencing data and can lead to artifactual findings. A
number of strategies have therefore been proposed to detect them. Building on the strengths …

The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …

Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …

Single-cell genomic technologies enable the multimodal profiling of millions of cells across
temporal and spatial dimensions. However, experimental limitations hinder the …

The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple
cardiac cell lineages during embryonic development and provides signals that are essential …

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is
characterized by dysfunction of insulin-producing pancreatic islet β cells1, 2. T2D genome …

Understanding the complexity of the long-lived HIV reservoir during antiretroviral therapy
(ART) remains a considerable impediment in research towards a cure for HIV. To address …

Caloric restriction (CR) can extend the organism life-and health-span by improving glucose
homeostasis. How CR affects the structure-function of pancreatic beta cells remains …