Uncovering an organ's molecular architecture at single-cell resolution by spatially resolved transcriptomics

J Liao, X Lu, X Shao, L Zhu, X Fan - Trends in biotechnology, 2021 - cell.com
Revealing fine-scale cellular heterogeneity among spatial context and the functional and
structural foundations of tissue architecture is fundamental within biological research and …

Review of single-cell RNA sequencing in the heart

S Yamada, S Nomura - International journal of molecular sciences, 2020 - mdpi.com
Single-cell RNA sequencing (scRNA-seq) technology is a powerful, rapidly developing tool
for characterizing individual cells and elucidating biological mechanisms at the cellular …

Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

T Yamaguchi, TS Sumida, S Nomura, M Satoh… - Nature …, 2020 - nature.com
Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the
role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in triggering heart …

[HTML][HTML] Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction

S Yamada, T Ko, S Hatsuse, S Nomura… - Nature Cardiovascular …, 2022 - nature.com
The underlying mechanisms of ventricular remodeling after myocardial infarction (MI) remain
largely unknown. In this study, we performed an integrative analysis of spatial …

Single-cell RNA Sequencing (scRNA-seq): Advances and Challenges for Cardiovascular Diseases (CVDs)

SU Khan, Y Huang, H Ali, I Ali, S Ahmad… - Current Problems in …, 2023 - Elsevier
Implementing Single-cell RNA sequencing (scRNA-seq) has significantly enhanced our
comprehension of cardiovascular diseases (CVDs), providing new opportunities to …

Single-cell RNA sequencing of the cardiovascular system: new looks for old diseases

F Chaudhry, J Isherwood, T Bawa, D Patel… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease encompasses a wide range of conditions, resulting in the highest
number of deaths worldwide. The underlying pathologies surrounding cardiovascular …

[HTML][HTML] Single-cell and spatial transcriptomics: Advances in heart development and disease applications

X Long, X Yuan, J Du - Computational and structural biotechnology journal, 2023 - Elsevier
Current transcriptomics technologies, including bulk RNA-seq, single-cell RNA sequencing
(scRNA-seq), single-nucleus RNA-sequencing (snRNA-seq), and spatial transcriptomics …

Single-cell genomics to understand disease pathogenesis

S Nomura - Journal of Human Genetics, 2021 - nature.com
Cells are minimal functional units in biological phenomena, and therefore single-cell
analysis is needed to understand the molecular behavior leading to cellular function in …

Cellular heterogeneity of the heart

N Anto Michel, S Ljubojevic-Holzer… - Frontiers in …, 2022 - frontiersin.org
Recent advances in technology such as the introduction of high throughput
multidimensional tools like single cell sequencing help to characterize the cellular …

Metabolism, epigenetics, and causal inference in heart failure

TH Kimball, TM Vondriska - Trends in Endocrinology & Metabolism, 2020 - cell.com
Eukaryotes must balance the metabolic and cell death actions of mitochondria via control of
gene expression and cell fate by chromatin, thereby functionally binding the metabolome …