The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
Targeting RTK signaling pathways in cancer
T Regad - Cancers, 2015 - mdpi.com
The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of
proliferation, differentiation and survival. The induction of these pathways depends on …
proliferation, differentiation and survival. The induction of these pathways depends on …
Targeting the phosphoinositide 3-kinase pathway in cancer
P Liu, H Cheng, TM Roberts, JJ Zhao - Nature reviews Drug discovery, 2009 - nature.com
Abstract The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system
that links oncogenes and multiple receptor classes to many essential cellular functions, and …
that links oncogenes and multiple receptor classes to many essential cellular functions, and …
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
JA Engelman - Nature Reviews Cancer, 2009 - nature.com
There are ample genetic and laboratory studies that suggest the PI3K–Akt pathway is vital to
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
RJ DeBerardinis, JJ Lum, G Hatzivassiliou… - Cell metabolism, 2008 - cell.com
Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all
macromolecular components during each passage through the cell cycle. It is therefore not …
macromolecular components during each passage through the cell cycle. It is therefore not …
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
JA Engelman, J Luo, LC Cantley - Nature Reviews Genetics, 2006 - nature.com
Abstract Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates
vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular …
vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular …
PTEN and the PI3-kinase pathway in cancer
N Chalhoub, SJ Baker - Annual Review of Pathology …, 2009 - annualreviews.org
PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …
Perturbations of the AKT signaling pathway in human cancer
DA Altomare, JR Testa - Oncogene, 2005 - nature.com
Abstract AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of
activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse …
activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse …
mTOR signaling in disease
E Dazert, MN Hall - Current opinion in cell biology, 2011 - Elsevier
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …
Oncogenic PI3K deregulates transcription and translation
There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer
pathogenesis. Experimental data document a requirement for deregulation of both …
pathogenesis. Experimental data document a requirement for deregulation of both …