The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

Chromosome segregation depends on the attachment of spindle microtubules to sites on
chromosomal DNA known as centromeres, through kinetochore protein complexes …

Unlike mild DNA damage exposure, DNA damage repair (DDR) is reported to be ineffective
in full-grown mammalian oocytes exposed to moderate or severe DNA damage. The …

Centromeres are no longer considered to be silent. Both centromeric and pericentric
transcription have been discovered, and their RNA transcripts have been characterized and …

Eukaryotes segregate their chromosomes during mitosis and meiosis by attaching
chromosomes to the microtubules of the spindle so that they can be distributed into daughter …

Precise positioning of the histone-H3 variant, CENP-A, ensures centromere stability and
faithful chromosomal segregation. Mislocalization of CENP-A to extra-centromeric loci …

Centromeres are highly specialised chromosome domains defined by the presence of an
epigenetic mark, the specific histone H3 variant called CENP-A (centromere protein A). They …

Centromeres are genomic regions essential for faithful chromosome segregation.
Transcription of noncoding RNA (ncRNA) at centromeres is important for their formation and …

To investigate how exogenous DNA concatemerizes to form episomal artificial
chromosomes (ACs), acquire equal segregation ability and maintain stable …

Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …