Next‐generation pathology practices with mass spectrometry imaging

HH Chung, P Huang, CL Chen, C Lee… - Mass Spectrometry …, 2023 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful technique that reveals the spatial distribution
of various molecules in biological samples, and it is widely used in pathology‐related …

Spatial proteomics for understanding the tissue microenvironment

Y Mao, X Wang, P Huang, R Tian - Analyst, 2021 - pubs.rsc.org
The human body comprises rich populations of cells, which are arranged into tissues and
organs with diverse functionalities. These cells exhibit a broad spectrum of phenotypes and …

Reduced hemoglobin signal and improved detection of endogenous proteins in blood-rich tissues for MALDI mass spectrometry imaging

M Lin, LS Eberlin, EH Seeley - Journal of the American Society for …, 2022 - ACS Publications
Mass spectrometry imaging provides a powerful approach for the direct analysis and spatial
visualization of molecules in tissue sections. Using matrix-assisted laser …

Chemical decrosslinking-based peptide characterization of formaldehyde-fixed rat pancreas using fluorescence-guided single-cell mass spectrometry

DK Lee, SS Rubakhin, JV Sweedler - Analytical chemistry, 2023 - ACS Publications
Approaches for the characterization of proteins/peptides in single cells of formaldehyde-
fixed (FF) tissues via mass spectrometry (MS) are still under development. The lack of a …

Reproducible lipid alterations in patient-derived breast cancer xenograft FFPE tissue identified with MALDI MSI for pre-clinical and clinical application

V Denti, MK Andersen, A Smith, AM Bofin, A Nordborg… - Metabolites, 2021 - mdpi.com
The association between lipid metabolism and long-term outcomes is relevant for tumor
diagnosis and therapy. Archival material such as formalin-fixed and paraffin embedded …

A Novel Strategy Based on Permanent Protein Modifications Induced by Formaldehyde for Food Safety Analysis

S Tian, R Liu, Z Wu, K Zhang - Analytical Chemistry, 2022 - ACS Publications
The illegal additions of chemicals in food products are serious incidents threatening current
public safety. To date, ideal methods to determine permanent traces of prohibited chemicals …

Visualization of Small Intact Proteins in Breast Cancer FFPE Tissue

M Giampà, MK Andersen, S Krossa, V Denti… - … : Methods and Protocols, 2023 - Springer
Molecular visualization of metabolites, lipids, and proteins by matrix-assisted laser
desorption/ionization mass spectrometry imaging (MALDI MSI) is becoming an in-demand …

MALDI mass spectrometry imaging and spatially-resolved proteomics

E Chicano-Galvez, M Salzet, I Fournier - 2021 - books.rsc.org
Proteins are major players of biological regulation and participate in the phenotypes
expressed by the organisms. Identifying the proteins, their regulation and spatial distribution …

Mass spectrometry imaging: the future is now

S Baijnath - Bioanalysis, 2022 - Taylor & Francis
Since its introduction, mass spectrometry (MS) imaging (MSI or IMS) has revolutionized all
areas of the scientific domain that have found applications for this rapidly developing …

MALDI Mass Spectrometry Imaging of Neuropeptides

J Hanrieder - 2021 - books.rsc.org
Neuropeptides, including peptide hormones, are key modulators in the brain that represent
the largest class of chemical messengers for cell-to-cell communication. 1–5 Due to the …