Activation of transcription requires alteration of chromatin by complexes that increase the
accessibility of nucleosomal DNA. Removing nucleosomes from regulatory sequences has …

Eukaryotic genomes are functionally organized into chromatin, a compact packaging of
nucleoproteins with the basic repeating unit known as the nucleosome. A major focus for the …

The nucleosome is a major modulator of DNA accessibility to other cellular factors.
Nucleosome positioning has a critical importance in regulating cell processes such as …

Chromatin accessibility of a promoter is fundamental in regulating transcriptional activity.
The histone variant H2A. Z has been shown to contribute to this regulation, but its role has …

The eukaryotic genome is organized into nucleosomes, the fundamental units of chromatin.
The positions of nucleosomes on DNA regulate protein-DNA interactions and in turn …

The organization of nucleosomes across functional genomic elements represents a critical
layer of control. Here, we present a strategy for high-resolution nucleosome profiling at …

Chromatin remodelers are ATP-dependent enzymes that are critical for reorganizing and
repositioning nucleosomes in concert with many basic cellular processes. For the …

We show that the physical distribution of nucleosomes at antigen receptor loci is subject to
regulated cell type-specific and lineage-specific positioning and correlates with the …

Nucleosomes are fundamental units of chromatin that play critical roles in gene regulation
by modulating DNA accessibility. However, their roles in regulating tissue-specific gene …

DNA helical twist imposes geometric constraints on the location of histone–DNA interaction
sites along nucleosomal DNA. Certain 10.5-bp periodic nucleotides in phase with these …