A sequence-based global map of regulatory activity for deciphering human genetics
Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we
still lack a systematic mapping from any sequence or variant to regulatory activities. We …
still lack a systematic mapping from any sequence or variant to regulatory activities. We …
Challenges in benchmarking metagenomic profilers
Accurate microbial identification and abundance estimation are crucial for metagenomics
analysis. Various methods for classification of metagenomic data and estimation of …
analysis. Various methods for classification of metagenomic data and estimation of …
Behavior-aware account de-anonymization on ethereum interaction graph
Blockchain technology has the characteristics of decentralization, traceability and tamper-
proof, which creates a reliable decentralized trust mechanism, further accelerating the …
proof, which creates a reliable decentralized trust mechanism, further accelerating the …
Accurate and fast cell marker gene identification with COSG
M Dai, X Pei, XJ Wang - Briefings in bioinformatics, 2022 - academic.oup.com
Accurate cell classification is the groundwork for downstream analysis of single-cell
sequencing data, yet how to identify true marker genes for different cell types still remains a …
sequencing data, yet how to identify true marker genes for different cell types still remains a …
Embryonic origins of adult pluripotent stem cells
JO Kimura, DM Bolaños, L Ricci, M Srivastava - Cell, 2022 - cell.com
Although adult pluripotent stem cells (aPSCs) are found in many animal lineages,
mechanisms for their formation during embryogenesis are unknown. Here, we leveraged …
mechanisms for their formation during embryogenesis are unknown. Here, we leveraged …
Systematic comparison of high-throughput single-cell and single-nucleus transcriptomes during cardiomyocyte differentiation
A comprehensive reference map of all cell types in the human body is necessary for
improving our understanding of fundamental biological processes and in diagnosing and …
improving our understanding of fundamental biological processes and in diagnosing and …
[HTML][HTML] Domestic dog lineages reveal genetic drivers of behavioral diversification
Selective breeding of domestic dogs has generated diverse breeds often optimized for
performing specialized tasks. Despite the heritability of breed-typical behavioral traits …
performing specialized tasks. Despite the heritability of breed-typical behavioral traits …
Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning
D Mitrovic, SE McComas, C Alleva, M Bonaccorsi… - Elife, 2023 - elifesciences.org
Sugar porters (SPs) represent the largest group of secondary-active transporters. Some
members, such as the glucose transporters (GLUTs), are well known for their role in …
members, such as the glucose transporters (GLUTs), are well known for their role in …
Mutational spectra are associated with bacterial niche
As observed in cancers, individual mutagens and defects in DNA repair create distinctive
mutational signatures that combine to form context-specific spectra within cells. We …
mutational signatures that combine to form context-specific spectra within cells. We …
Zero-shot drug repurposing with geometric deep learning and clinician centered design
Of the several thousand diseases that affect humans, only about 500 have treatments
approved by the US Food and Drug Administration. Even for those with approved …
approved by the US Food and Drug Administration. Even for those with approved …