De novo biosynthesis of fatty acids is an iterative process requiring strict regulation of the
lengths of the produced fatty acids. In this review, we focus on the factors determining chain …

Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of
natural product with a broad range of biological activities. Polyketide synthases (PKSs) …

Megasynthases, such as type I fatty acid and polyketide synthases (FASs and PKSs), are
multienzyme complexes responsible for producing primary metabolites and complex natural …

Covering: up to April 5, 2018 Metabolites from type II fatty acid synthase (FAS) and
polyketide synthase (PKS) pathways differ broadly in their identities and functional roles …

In type II polyketide synthases (PKSs), the ketosynthase–chain length factor (KS–CLF)
complex catalyzes polyketide chain elongation with the acyl carrier protein (ACP). Highly …

Covering: up to early 2018 The Nonribosomal Peptide Synthetases (NRPSs) and Polyketide
Synthases (PKSs) are families of modular enzymes that produce a tremendous diversity of …

Type II nonribosomal peptide synthetases (NRPS) generate exotic amino acid derivatives
that, combined with additional pathways, form many bioactive natural products. One family of …

While type II polyketide synthases (PKSs) are known for producing aromatic compounds, a
phylogenetically new subfamily of type II PKSs have been recently proposed to synthesize …

Polyketides are a large class of structurally and functionally diverse natural products with
important bioactivities. Many polyketides are synthesized by reducing type II polyketide …

Polyketides are a large family of structurally complex natural products including compounds
with important bioactivities. Polyketides are biosynthesized by polyketide synthases (PKSs) …