All trans retinoic acid (ATRA) has revolutionized the therapy of acute promyelocytic leukemia
(APL). Treatment of this leukemia with ATRA in combination with chemotherapy has resulted …

The p53 gene family members p53, p73, and p63 display several isoforms derived from the
presence of internal promoters and alternative splicing events. They are structural homologs …

Infiltration of tumor-promoting immune cells is a strong driver of tumor progression.
Especially the accumulation of macrophages in the tumor microenvironment is known to …

Recent years have seen an increasing number of genetically engineered pig models of
human diseases including cancer. We previously generated pigs with a modified TP53 …

The introduction of all-trans retinoic acid combined with anthracyclines has significantly
improved the outcomes for patients diagnosed with acute promyelocytic leukemia (APL) …

In a significant number of cases cancer therapy is followed by a resurgence of more
aggressive tumors derived from immature cells. One example is acute myeloid leukemia …

Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3b1 subunit of the
spliceosome. There is considerable interest in the compound as a tool to study SF3b1 …

A major goal of cancer genomics is to identify all genes that play critical roles in
carcinogenesis. Most approaches focused on genes positively selected for mutations that …

Aberrant alternative splicing events (AASEs) are key biological processes for tumorigenesis
and the rationale for designing splice-switching oligonucleotides (SSOs). However, the …

Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Studies in hematological malignancies have …