In human beings, two forms of GnRH, termed GnRH-I and GnRH-II, encoded by separate
genes have been identified. Although these hormones share comparable cDNA and …

Gonadotropin‐releasing hormone (GnRH) has historically been known as a pituitary
hormone; however, in the past few years, interest has been raised in locally produced …

Purpose: We have reported previously that tumors expressing wild-type epidermal growth
factor receptor (EGFR) in a murine model are sensitive to the EGFR tyrosine kinase inhibitor …

The hematopoietic-specific Gα 16 protein has recently been shown to mediate receptor-
induced activation of the signal transducer and activator of transcription 3 (STAT3). In the …

Rapid engagement of the extracellular signal-regulated kinase (ERK) cascade via the G
q/11-coupled GnRH receptor (GnRHR) is mediated by transactivation of the epidermal …

Objectives Ghrelin is a brain-gut peptide with GH-releasing and appetite-inducing activities
and a widespread tissue distribution. Ghrelin is the endogenous ligand of the GH …

G protein-coupled receptors (GPCRs) mediate cellular responses to a diverse array of
extracellular messenger molecules. Recent studies have shown that GPCR-mediated …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
function as ligand-activated transcription factors regulating lipid metabolism and …

The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor
ligands, EGF, TGFα, and heregulin are differentially expressed in normal gonadotroph and …

The role of ERK, Jun N-terminal kinase (JNK), p38, and c-Src in GnRH-stimulated FSHβ-
subunit promoter activity was examined in the LβT-2 gonadotroph cell line. Incubation of the …