Current and promising pharmacotherapeutic options for candidiasis

L Scorzoni, BB Fuchs, JC Junqueira… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Candida spp. are commensal yeasts capable of causing infections such as
superficial, oral, vaginal, or systemic infections. Despite medical advances, the antifungal …

Dissecting the anti-biofilm potency of kappa-carrageenan capped silver nanoparticles against Candida species

P Gupta, A Goel, KR Singh, MK Meher, K Gulati… - International Journal of …, 2021 - Elsevier
Global antimicrobial crisis and advent of drug resistant fungal strains has substantially
distressed disease management for clinicians. Biodegradable silver nanoparticles (AgNps) …

Effectiveness of Phytoactive Molecules on Transcriptional Expression, Biofilm Matrix, and Cell Wall Components of Candida glabrata and Its Clinical Isolates

P Gupta, S Gupta, M Sharma, N Kumar, V Pruthi… - ACS …, 2018 - ACS Publications
Toxicity challenges by antifungal arsenals and emergence of multidrug resistance scenario
has posed a serious threat to global community. To cope up with this alarming situation …

Geraniol eradicates Candida glabrata biofilm by targeting multiple cellular pathways

P Gupta, H Gupta, KM Poluri - Applied Microbiology and Biotechnology, 2021 - Springer
Global burden of fungal infections and associated health risk has accelerated at an
incredible pace and needs to be attended at the earliest with an unbeatable therapeutic …

Mechanistic insights into Candida biofilm eradication potential of eucalyptol

P Gupta, V Pruthi, KM Poluri - Journal of Applied Microbiology, 2021 - academic.oup.com
Aim Candida‐associated fungal infections are prevalent in hospitalized and immune‐
compromised patients. Their biofilm architecture and high rate of antifungal resistance make …

Assessing the eradication potential of fungal biofilms using acacia gum/PVA nanofibers functionalized with geraniol-β cyclodextrin inclusion complex

P Gupta, P Mishra, N Verma, J Alhariry, C Kumar… - Journal of Drug Delivery …, 2024 - Elsevier
The world is witnessing severe fungal co-infections with incidences of antifungal resistance
and increased morbidity/mortality. The present study is focused on fabricating geraniol …

Molecular investigations on Candida glabrata clinical isolates for pharmacological targeting

H Gupta, P Gupta, M Kairamkonda, KM Poluri - RSC advances, 2022 - pubs.rsc.org
Prevalence of drug resistant C. glabrata strains in hospitalized immune-compromised
patients with invasive fungal infections has increased at an unexpected pace. This has …

Amlodipine and lufenuron as repurposing drugs against Sporothrix brasiliensis

VR Poester, JED Hidalgo, LS Jardim, MR Trápaga… - PeerJ, 2023 - peerj.com
Background Sporotrichosis caused by Sporothrix brasiliensis is a globally emerging
infectious disease with limited therapeutic options. Thus, we aimed to evaluate the in vitro …

Elucidating the lactic acid tolerance mechanism in vaginal clinical isolates of Candida glabrata

P Gupta, H Gupta, M Kairamkonda, N Kumar… - Medical …, 2022 - academic.oup.com
Incidence of vulvovaginal candidiasis are strikingly high and treatment options are limited
with nearly 50% Candida glabrata cases left untreated or experience treatment failures. The …

Functional characterization of Candida glabrata ORF, CAGL0M02233g for its role in stress tolerance and virulence

P Gupta, RC Meena, N Kumar - Microbial Pathogenesis, 2020 - Elsevier
Present investigation is aimed to analyze the role of an uncharacterized ORF of Candida
glabrata (CBS138), CAGL0M02233g (an ortholog of RAD53, a key DNA checkpoint effector …