Palladium catalysed cross-couplings reactions have been a dominant method in synthetic
chemistry for decades. Despite this, the role of the solvent is often taken for granted and …

This Review examines parts per million (ppm) palladium concentrations in catalytic cross-
coupling reactions and their relationship with mole percentage (mol%). Most studies in …

The construction of allylic quaternary sp3‐carbon centers has long been a formidable
challenge in transition‐metal‐catalyzed alkyl‐allyl coupling reactions due to the severe …

Small, strained ring systems are important pharmacophores in medicinal chemistry and
versatile intermediates in organic synthesis. However, the kinetic and thermodynamic …

Azetidines, being four‐membered N‐heterocycles, possess significant potential in
contemporary medicinal chemistry owing to their favorable pharmacokinetic properties …

The 1, 3-butadiene motif is widely found in many natural products and drug candidates with
relevant biological activities. Moreover, dienes are important targets for synthetic chemists …

A family of single-component iron precatalysts for the [4+ 4]-cyclodimerization and
intermolecular cross-[4+ 4]-cycloaddition of monosubstituted 1, 3-dienes is described …

Sequential C− H functionalization of molecules containing multiple C− H bonds can
efficiently lead to structural diversity. Herein we present the first chelation‐assisted …

Recent years have seen the emergence of transition metal catalyzed C–H activation as a
powerful synthetic tool in organic chemistry. Allenes have fascinated synthetic chemists due …

The efficient and stereoselective synthesis of polysubstituted butadienes, especially the
multifunctional butadienes, represents a great challenge in organic synthesis. Herein, we …