Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

Inhibitors of cyclin-dependent kinases (CDKs) 4/6 have emerged as a powerful class of
agents with clinical activity in several malignancies. Targeting the cell cycle represents a …

Cyclin D-dependent kinases (CDK4 and CDK6) are positive regulators of cell cycle entry
and they are overactive in the majority of human cancers. However, it is currently not …

The recent clinical success of targeted therapies in melanoma directed at the oncogene
BRAF validates the concept of targeting oncogenes. The p16-cyclin D-CDK4/6 …

MicroRNAs (miRNAs) regulate gene expression by repressing translation or directing
sequence-specific degradation of complementary mRNA. Here, we report that expression of …

Loss of the tumor suppressor gene CDKN2A, encoding p16 and p14, is a frequent event
driving melanoma progression. Therefore, therapeutic strategies aimed at CDKN2A loss …

During the aging process or disease progression, normal cells and tissues in the body
undergo various stresses, leading to cell damage and the need for repair, adaptation …

Oncogene-induced senescence (OIS) is characterized by increased expression of the cell
cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context …

Data accumulating during the last two decades suggest that tumorigenesis is held in check
by two major intrinsic failsafe mechanisms; apoptosis and cellular senescence. While …

A large proportion of human melanomas harbor a mutation leading to permanent activation
of the serine/threonine kinase BRAF, and as a consequence, they have developed …