Glia are the most numerous cells in the brain, and their many diverse functions highlight
their essential role in the nervous system. Recent studies have revealed an unexpected new …

The main focus of this review is the role of mammary stem cells in normal breast
development and carcinogenesis. We have developed a new in vitro culture system that …

Although the existence of mammary stem cells has been suggested by serial transplantation
studies in mice, their identification has been hindered by the lack of specific surface markers …

Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified
by the'side-population'(SP) phenotype. Although it has been assumed that expression of …

Pediatric brain tumors are significant causes of morbidity and mortality. It has been
hypothesized that they derive from self-renewing multipotent neural stem cells. Here, we …

The 293 cell line was derived by transformation of primary cultures of human embryonic
kidney (HEK) cells with sheared adenovirus (Ad) 5 DNA. A combination of immunostaining …

The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were
compared to define a genetic program for stem cells. A total of 216 genes are enriched in all …

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are
poorly understood. We determined global gene expression profiles for mouse and human …

Neural stem cells in the subventricular zone (SVZ) continue to generate new neurons in the
adult brain. SVZ cells exposed to EGF in culture grow to form neurospheres that are …

The mechanisms controlling neural stem cell proliferation are poorly understood. Here we
demonstrate that the PTEN tumor suppressor plays an important role in regulating neural …