Targeting galectin-driven regulatory circuits in cancer and fibrosis

KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression

MR Girotti, M Salatino, T Dalotto-Moreno… - Journal of Experimental …, 2019 - rupress.org
Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

New biologically potent benzimidazole‐based‐triazole derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors along with molecular docking study

Y Khan, W Rehman, R Hussain, S Khan… - Journal of …, 2022 - Wiley Online Library
A series of fifteen hybrid analogs (1–15) based on benzimidazole bearing triazole skeleton
were synthesized and were evaluated for in vitro AChE and BuChE inhibition profile. All the …

Glycans as biomarkers in prostate cancer

E Scott, J Munkley - International journal of molecular sciences, 2019 - mdpi.com
Prostate cancer is the most commonly diagnosed malignancy in men, claiming over 350,000
lives worldwide annually. Current diagnosis relies on prostate-specific antigen (PSA) testing …

Galectin-1: a traditionally immunosuppressive protein displays context-dependent capacities

X Yu, J Qian, L Ding, S Yin, L Zhou… - International Journal of …, 2023 - mdpi.com
Galectin–Carbohydrate interactions are indispensable to pathogen recognition and immune
response. Galectin-1, a ubiquitously expressed 14-kDa protein with an evolutionarily …

Immunosuppressive roles of galectin-1 in the tumor microenvironment

Y Huang, HC Wang, J Zhao, MH Wu, TC Shih - Biomolecules, 2021 - mdpi.com
Evasion of immune surveillance is an accepted hallmark of tumor progression. The
production of immune suppressive mediators by tumor cells is one of the major mechanisms …

Impact of galectins in resistance to anticancer therapies

P Navarro, N Martínez-Bosch, AG Blidner… - Clinical Cancer …, 2020 - AACR
Galectins are an endogenous family of β-galactoside-binding proteins that play complex and
multifaceted roles at various stages of cancer progression, including modulation of tumor …

The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer

K Hodgson, M Orozco-Moreno, E Scott, R Garnham… - Scientific reports, 2023 - nature.com
Prostate cancer is the most common cancer in men and a major cause of cancer related
deaths worldwide. Nearly all affected men develop resistance to current therapies and there …

KIT Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer

AT Funkhouser, AM Strigenz, BB Blair, AP Miller… - Cancers, 2022 - mdpi.com
Simple Summary Galectins are a family of β-galactoside binding proteins whose levels are
altered in various stages of different types of cancer. This study provides an analytical …

Glycosylation changes in prostate cancer progression

W Butler, J Huang - Frontiers in oncology, 2021 - frontiersin.org
Prostate Cancer (PCa) is the most commonly diagnosed malignancy and second leading
cause of cancer-related mortality in men. With the use of next generation sequencing and …