The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …

(1) Background: Various epidemiological studies suggest that oxidative stress and disrupted
neuronal function are mechanistically linked to neurodegenerative diseases (NDs) …

The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor
23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes …

As the global population ages, the need to prolong lifespan and healthspan becomes
increasingly imperative. Understanding the molecular determinants underlying cognitive …

Background: Autophagy is a conserved physiological intracellular mechanism responsible
for the degradation and recycling of cytoplasmic constituents (eg, damaged organelles, and …

As a neurodegenerative disease, Alzheimer's disease (AD) shows a higher incidence during
the aging process, mainly revealing the characteristics of a significant decrease in cognition …

The highly complex pathophysiology of Alzheimer's disease (AD) and the low bioavailability
of the currently used drugs make it necessary to offer versatile treatment options. In this …

Objective We aimed to evaluate the prognostic performance of circulating Klotho in coronary
atherosclerotic disease (CAD), and to further explore the effect of Klotho on stress-mediated …

In this research, some new heterocyclic hydrazone compounds bearing an aryl sulfonate
moiety (2 a–i) were facilely synthesized for the first time and elucidated by some …