We reassess progress in the field of biomolecular modeling and simulation, following up on
our perspective published in 2011. By reviewing metrics for the field's productivity and …

While significant advances have been made in predicting static protein structures, the
inherent dynamics of proteins, modulated by ligands, are crucial for understanding protein …

The recent revolution in imaging techniques and results from RNA footprinting in situ reveal
how the bacteriophage MS2 genome regulates both particle assembly and genome release …

To function, biomolecules require sufficient specificity of interaction as well as stability to live
in the cell while still being able to move. Thermodynamic stability of only a limited number of …

Bacteriophage T7 gp4 helicase has served as a model system for understanding
mechanisms of hexameric replicative helicase translocation. The mechanistic basis of how …

Three-dimensional protein structures, whether determined experimentally or theoretically,
are often too low resolution. In this mini-review, we outline the computational methods for …

Recently several techniques have emerged that significantly enhance the quality of
predictions of protein tertiary structures. In this study, we describe the performance of …

The phase problem in X-ray crystallography arises from the fact that only the intensities, and
not the phases, of the diffracting electromagnetic waves are measured directly. Molecular …

Recent advances in machine learning, bioinformatics, and the understanding of the folding
problem have enabled efficient predictions of protein structures with moderate accuracy …

Disrupted-in-schizophrenia-1 (DISC1) is a scaffold protein of significant importance for
neuro-development and a prominent candidate protein in the etiology of mental disorders. In …