Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …

A distinguishing phenotype of solid tumors is the presence of an alkaline cellular feature
despite the surrounding acidic microenvironment. This phenotypic characteristic of tumors …

Abstract Water channels, aquaporins (AQPs), are a family of small integral plasma
membrane proteins that primarily transport water across the plasma membrane. There are …

Mitochondrial respiration is responsible for more than 90% of oxygen consumption in
humans. Cells utilize oxygen as the final electron acceptor in the aerobic metabolism of …

Oxygen (O2) is a substrate for energy production in the cell and is a rapid regulator of
cellular metabolism. Recent studies have also implicated O2 and its signal transduction …

The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to
CO2 and NH3. Here, we use changes in surface pH (pHS) to assess relative CO2 vs. NH3 …

Background Aquaporin (AQP) water channels are best known as passive transporters of
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …

Aquaporins (AQPs) were originally identified as channels facilitating water transport across
the plasma membrane. They have a pair of highly conserved signature sequences …

Cellular oxygen consumption is a determinant of intracellular oxygen levels. Because of the
high demand of mitochondrial respiration during insulin secretion, pancreatic β-cells …

The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …