There is strong evidence that serum free bilirubin concentration has significant effects on
morbidity and mortality in the most significant health conditions of our times, including …

A diabetic foot ulcer (DFU) is one of the major complications of diabetes. Wound healing
under diabetic conditions is often impaired. This is in part due to the excessive oxidative …

Bilirubin is a yellow-colored metabolite of heme degradation (a bile pigment), once believed
to be toxic, but recently recognized as a powerful endogenous antioxidant of physiologic …

Rosmarinic acid (RA), which is a natural polyphenol, was isolated from Rosmarinus.
officinalis L. The aim of this study is to evaluate the effects of rosmarinic acid on liver and …

Non-healing wounds in patients with diabetes are a concerning issue associated with
amputation and a high mortality rate. These wounds are exacerbated by oxidative stress and …

Chronic diabetic wounds pose a serious threat to human health and safety because of their
refractory nature and high recurrence rates. The formation of refractory wounds is associated …

Among antioxidants in the human body, bilirubin has been recognized over the past 20
years to afford protection against different chronic conditions, including inflammation and …

Bilirubin has shown cutaneous wound healing potential in some preliminary studies. Here
we hypothesize that bilirubin facilitates wound healing in diabetic rats by modulating …

Diabetes mellitus is a metabolic disorder with persistent hyperglycemia caused by a variety
of underlying factors. Chronic hyperglycemia can lead to diverse serious consequences and …

Islet transplantation is the experimental strategy to treat type 1 diabetes by transplanting
isolated islets from a donor pancreas into the recipient. While significant progress has been …