Abstract Renal Cell Carcinoma (RCC) has the highest mortality rate of the genitourinary
cancers and the incidence of RCC has risen steadily. If detected early, RCC is curable by …

Abstract Birt–Hogg–Dubé (BHD) syndrome is an inherited renal cancer syndrome in which
affected individuals are at risk of developing benign cutaneous fibrofolliculomas, bilateral …

To further understand the molecular distinctions between kidney cancer subtypes, we
analyzed exome, transcriptome and copy number alteration data from 167 primary human …

Germline mutations in the novel tumor suppressor gene FLCN are responsible for the
autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that predisposes to …

Renal cell carcinoma (RCC), the most lethal type of genitourinary cancer, is generally
resistant to chemotherapy and radiation therapy. Surgical excision of the tumor at a localized …

Kidney cancer is not a single disease; it is made up of a number of different types of cancer,
including clear cell, type 1 papillary, type 2 papillary, chromophobe, TFE3, TFEB, and …

Growing tumors exist in metabolically compromised environments that require activation of
multiple pathways to scavenge nutrients to support accelerated rates of growth. The folliculin …

Mutations in mitochondrial DNA (mtDNA) are frequent in cancers but it is not yet clearly
established whether they are modifier events involved in cancer progression or whether they …

Renal cell carcinoma (RCC) is not a single disease, but comprises a group of tumors of
renal epithelial origin, each with a different histology, displaying a different clinical course …

Aerobic glycolysis in cancer cells, also known as the 'Warburg effect', is driven by
hyperactivity of lactate dehydrogenase A (LDHA). LDHA is thought to be a substrate …