Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Fibroblasts are activated to repair the heart following injury. Fibroblast activation in the
mammalian heart leads to a permanent fibrotic scar that impairs cardiac function. In other …

How do some animals like crabs, flatworms and salamanders regenerate entire body parts
after a severe injury? Which are the mechanisms and how did that regenerative ability …

Zebrafish have a lifelong cardiac regenerative ability after damage, whereas mammals lose
this capacity during early postnatal development. This study investigated whether the …

The eIF4E family of translation initiation factors bind 5′ methylated caps and act as the
limiting step for mRNA translation. The canonical eIF4E1A is required for cell viability, yet …

Teleost zebrafish and neonatal mammalian hearts exhibit the remarkable capacity to
regenerate through dedifferentiation and proliferation of pre-existing cardiomyocytes (CMs) …

ABSTRACT In February 2016, The Company of Biologists hosted an intimate gathering of
leading international researchers at the forefront of experimental cardiovascular …

Fibroblasts are activated to repair the heart following injury. Fibroblast activation in the
mammalian heart leads to a permanent fibrotic scar that impairs cardiac function. In other …