Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …

Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …

Studies over the past 20 years have defined the Hippo signaling pathway as a major
regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …

Stem cell (SC) activity fluctuates throughout an organism's lifetime to maintain homeostatic
conditions in all tissues. As animals develop and age, their organs must remodel and …