Pyrazole scaffold: a remarkable tool in the development of anticancer agents

H Kumar, D Saini, S Jain, N Jain - European Journal of Medicinal Chemistry, 2013 - Elsevier
Pyrazole has been the topic of interest for thousands of researchers across the world
because of its wide spectrum pharmacological activities. Various structural modifications of …

[HTML][HTML] The antifungal activity of naphthoquinones: An integrative review

PG FERREIRA, CD NICOLETTI… - Anais da Academia …, 2018 - SciELO Brasil
Naphthoquinones are the most commonly occurring type of quinones in nature. They are a
diverse family of secondary metabolites that occur naturally in plants, lichens and various …

Synthesis, structure–activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives

S Mert, R Kasımoğulları, T Iça, F Çolak, A Altun… - European journal of …, 2014 - Elsevier
A series of pyrazole-3-carboxylic acid and pyrazole-3, 4-dicarboxylic acid derivatives were
synthesized, the structures were confirmed by their NMR (1 H and 13 C) and FT-IR spectra …

Synthesis and antimicrobial activities of novel 1, 5-diaryl pyrazoles

RV Ragavan, V Vijayakumar, NS Kumari - European journal of medicinal …, 2010 - Elsevier
Novel 1, 5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-
3-carboxamides (2a–e, 3, 3a–f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-yl) …

New lead structures in antifungal drug discovery

C Sheng, W Zhang - Current medicinal chemistry, 2011 - ingentaconnect.com
During the past two decades, the incidence of invasive fungal infections has been
increasing dramatically. Clinical available antifungal agents have several drawbacks such …

Design, synthesis, and biological evaluation of 1, 2, 3-trisubstituted-1, 4-dihydrobenzo [g] quinoxaline-5, 10-diones and related compounds as antifungal and …

VK Tandon, DB Yadav, HK Maurya… - Bioorganic & medicinal …, 2006 - Elsevier
A series of (S)-N-(3-chloro-1, 4-naphthoquinon-2-yl)-α-amino acid ethyl esters 3 and 1, 2, 3-
trisubstituted-1, 4-dihydrobenzo [g] quinoxaline-5, 10-diones 6–23 were synthesized and …

Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity

AM Farag, AS Mayhoub, SE Barakat… - Bioorganic & medicinal …, 2008 - Elsevier
The versatile synthons 4-(2-bromoacetyl)-5-methyl-1-phenyl-3-phenylcarbamoyl-1H-
pyrazole (3) and 4-[(E)-3-(dimethylamino) acryloyl]-5-methyl-1-phenyl-3-phenylcarbamoyl …

[HTML][HTML] Synthesis, characterization and antimicrobial evaluation of novel halopyrazole derivatives

ZN Siddiqui, F Farooq, TNM Musthafa, A Ahmad… - Journal of Saudi …, 2013 - Elsevier
Two novel halopyrazole derivatives (3, 5) were synthesized from 5-chloro-3-methyl-1-
phenylpyrazole-4-carboxaldehyde (1) using appropriate synthetic routes. Newly synthesized …

'On water': unprecedented nucleophilic substitution and addition reactions with 1, 4-quinones in aqueous suspension

VK Tandon, HK Maurya - Tetrahedron Letters, 2009 - Elsevier
Unique nucleophilic substitution and addition reactions of 1, 4-quinones in aqueous
suspension with aromatic amines, primary aliphatic amines, amino acid, ester of amino acid …

Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents

ZN Siddiqui, TNM Musthafa, A Ahmad… - Bioorganic & medicinal …, 2011 - Elsevier
A novel approach was adopted for the synthesis of series of new pyrazolyl chalcones (3a–c)
by the reaction of 5-chloro-3-methyl-1-phenylpyrazole-4-carboxaldehyde (1) with different 5 …