Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …

The roles of HOX transcription factors as oncogenes and tumor suppressor genes, and the
NF-KB pathway in chronic inflammation, both leading to cancer are well-established. HOX …

Emerging evidence has revealed that miRNAs could upregulate the expression levels of
target genes. However, the molecular mechanism underlying upregulation of targets …

The HOX genes are a highly conserved group of transcription factors that have key roles in
early development, but which are also highly expressed in most cancers. Many studies have …

Long noncoding RNAs (lncRNAs) have been reported to drive key cancer pathways but the
functions of majority of lncRNAs are unknown making a case for comprehensive functional …

Constitutional mismatch repair-deficiency: current problems and emerging therapeutic
strategies - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

In recent, intra-and inter-tumor heterogeneity is seen as one of key factors behind success
and failure of chemotherapy. Incessant use of doxorubicin (DOX) drug is associated with …

Homeodomain-containing gene 10 (HOXC10) is a member of the homeobox transcription
factors that plays an important role in the development of multicellular organisms. HOXC10 …

Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a
crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the …

While KRAS mutations are common in non-small cell lung cancer (NSCLC), effective
treatments are lacking. Here, we report that half of KRAS-mutant NSCLCs aberrantly …