Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury
V Kumar - Frontiers in immunology, 2020 - frontiersin.org
The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …
epithelial surface in direct contact with the external environment. It also serves as a crucial …
[HTML][HTML] New insights into the mechanisms of pulmonary edema in acute lung injury
R Herrero, G Sanchez, JA Lorente - Annals of Translational …, 2018 - ncbi.nlm.nih.gov
Appearance of alveolar protein-rich edema is an early event in the development of acute
respiratory distress syndrome (ARDS). Alveolar edema in ARDS results from a significant …
respiratory distress syndrome (ARDS). Alveolar edema in ARDS results from a significant …
[HTML][HTML] von Willebrand factor and inflammation
C Kawecki, PJ Lenting, CV Denis - Journal of Thrombosis and Haemostasis, 2017 - Elsevier
Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic
role in serving as a molecular bridge linking platelets to subendothelial components …
role in serving as a molecular bridge linking platelets to subendothelial components …
Endothelial destabilization by angiopoietin-2 via integrin β1 activation
Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine
kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation …
kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation …
The biology of IQGAP proteins: beyond the cytoskeleton
IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …
Renal endothelial injury and microvascular dysfunction in acute kidney injury
SK Verma, BA Molitoris - Seminars in nephrology, 2015 - Elsevier
The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …
a number of tightly controlled, complex and interdependent processes. Renal endothelial …
Nongenomic actions of thyroid hormone: the integrin component
The extracellular domain of plasma membrane integrin αvβ3 contains a cell surface receptor
for thyroid hormone analogues. The receptor is largely expressed and activated in tumor …
for thyroid hormone analogues. The receptor is largely expressed and activated in tumor …
SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19
The unprecedented global COVID-19 pandemic has prompted a desperate international
effort to accelerate the development of anti-viral candidates. For unknown reasons, COVID …
effort to accelerate the development of anti-viral candidates. For unknown reasons, COVID …
Integrin-Dependent Cell–Matrix Adhesion in Endothelial Health and Disease
J Aman, C Margadant - Circulation Research, 2023 - Am Heart Assoc
The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating
blood vessel formation and barrier function. Proper composition and function of the …
blood vessel formation and barrier function. Proper composition and function of the …
Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy
E Dodagatta-Marri, HY Ma, B Liang, J Li, DS Meyer… - Cell reports, 2021 - cell.com
Summary αvβ8 integrin, a key activator of transforming growth factor β (TGF-β), inhibits anti-
tumor immunity. We show that a potent blocking monoclonal antibody against αvβ8 (ADWA …
tumor immunity. We show that a potent blocking monoclonal antibody against αvβ8 (ADWA …