Covering 1970–2001This review covers the functionally diverse type III polyketide synthase
(PKS) superfamily of plant and bacterial biosynthetic enzymes, from the discovery of …

Covering: 2002 to 2009 This review covers recent advances in structure and function studies
on the chalcone synthase (CHS) superfamily of plant type III polyketide synthases (PKSs) …

Recent studies of moonlighting functions and catalytic promiscuity provide insights into the
structural and mechanistic bases of these phenomena. Moonlighting proteins that are …

Phenolic secondary metabolites are only produced by plants wherein they play important
roles in both biotic and abiotic defense in seed plants as well as being potentially important …

Polyketides represent an important class of biologically active and structurally diverse
compounds in nature. They are synthesized from acyl‐coenzyme A substrates by polyketide …

Malonyl-CoA is an important central metabolite for the production of diverse valuable
chemicals including natural products, but its intracellular availability is often limited due to …

Polyketide synthases (PKSs) catalyze the sequential condensation of simple acetate units to
produce a large class of natural products, including pharmacologically valuable compounds …

Abstract “There's life in the old dog yet!” This adage also holds true for natural product
research. After the era of natural products was declared to be over, because of the …

Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic
fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA …

Alkylresorcinol moieties of cannabinoids are derived from olivetolic acid (OLA), a polyketide
metabolite. However, the polyketide synthase (PKS) responsible for OLA biosynthesis has …