Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal
fluid barrier (BCSFB) in the developing and mature brain. The ChP is considered the primary …

Abstract α-Klotho is well described as an anti-aging protein, with critical roles in kidney
function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α …

The accumulation of the neurotoxin beta-amyloid (Aβ) is a major hallmark in Alzheimer's
disease (AD). Aβ homeostasis in the brain is governed by its production and various …

The role of the choroid plexus (CP) in brain homeostasis is being increasingly recognized
and recent studies suggest that the CP has a more important role in physiological and …

While the impact of hemorrhagic and ischemic strokes on the blood–brain barrier has been
extensively studied, the impact of these types of stroke on the choroid plexus, site of the …

The neurovascular unit (NVU) coordinates many essential functions in the brain including
blood flow control, nutrient delivery, and maintenance of BBB integrity. These functions are …

Purpose.: Bietti crystalline dystrophy (BCD) is a rare, autosomal recessive, progressive,
degenerative eye disease caused by mutations in the CYP4V2 gene, for which no …

The blood–brain barrier (BBB) is a complex physiological structure formed by the blood
vessels of the central nervous system (CNS) that tightly regulates the movement of …

The choroid plexus (CP) is a highly vascularized tissue in the brain ventricles and acts as
the blood-cerebrospinal fluid (CSF) barrier (BCSFB). A main function of the CP is to secrete …

The current review assesses the collection of mouse driver lines that have been instrumental
is identifying genes required for blood vessel formation, remodeling, maintenance …