Solid organ transplant recipients require long-term immunosuppression for prevention of
rejection. Calcineurin inhibitor (CNI)-based immunosuppressive regimens have remained …

Abstract RNA-sequencing (RNA-seq) is a technique to determine the order of nucleotides in
an RNA segment. Modern sequencing platforms simultaneously sequence millions of RNA …

Acute rejection of human allografts has been viewed mostly through the lens of adaptive
immunity, and the intragraft landscape of innate immunity genes has not been characterized …

Dissecting the human kidney allograft transcriptome: single-... : Current Opinion in Organ
Transplantation Dissecting the human kidney allograft transcriptome: single-cell RNA …

Gene expression analysis is emerging as a new diagnostic tool in transplant pathology, in
particular for the diagnosis of antibody-mediated rejection. Diagnostic gene expression …

Single-cell RNA sequencing (scRNA-seq) is a comprehensive technical tool to analyze
intracellular and intercellular interaction data by whole transcriptional profile analysis. Here …

Abstract Purpose of Review Progress in biology and medicine relies on technological
advances. The ability to examine gene expression from single cells in tissues with complex …

Antibody-mediated rejection (ABMR) is the major cause of chronic allograft dysfunction and
loss in kidney transplantation. The immunological mechanisms of ABMR that have been …

Recently developed single-cell profiling technologies hold promise to provide new insights
including analysis of population heterogeneity and linkage of antigen receptors with gene …

Banff Schema of classification of allograft histology has standardized reporting of tissue
pathology internationally greatly impacting clinical care and research. Inherent sampling …