Oxidative stress and 4‐hydroxy‐2‐nonenal (4‐HNE): Implications in the pathogenesis and treatment of aging‐related diseases

Y Li, T Zhao, J Li, M Xia, Y Li, X Wang… - Journal of …, 2022 - Wiley Online Library
Oxidative stress plays an important role in the development of aging‐related diseases by
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …

Oxidative stress and regeneration

M Jaganjac, L Milkovic, N Zarkovic… - Free Radical Biology and …, 2022 - Elsevier
Regeneration is the process of replacing/restoring a damaged cell/tissue/organ to its full
function and is limited respecting complexity of specific organ structures and the level of …

Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets

J Kopecka, P Trouillas, AČ Gašparović, E Gazzano… - Drug resistance …, 2020 - Elsevier
Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

Targeting lipid peroxidation for cancer treatment

SM Clemente, OH Martínez-Costa, M Monsalve… - Molecules, 2020 - mdpi.com
Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer
and its prognosis are very dependent on the affected tissue, body location, and stage at …

[HTML][HTML] DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity

F Gentile, A Arcaro, S Pizzimenti, M Daga… - AIMS …, 2017 - thieme-connect.com
Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage
and excess caloric intake cause generalized DNA damage, producing genotoxic and …

[HTML][HTML] Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

L Andrisic, D Dudzik, C Barbas, L Milkovic, T Grune… - Redox biology, 2018 - Elsevier
Association of oxidative stress with carcinogenesis is well known, but not understood well,
as is pathophysiology of oxidative stress generated during different types of anti-cancer …

Oxidative stress-related mechanisms in melanoma and in the acquired resistance to targeted therapies

S Pizzimenti, S Ribero, MA Cucci, M Grattarola… - Antioxidants, 2021 - mdpi.com
Melanoma is a highly aggressive cancer with the poorest prognosis, representing the
deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic …

Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation

A Jastrząb, A Gęgotek, E Skrzydlewska - Cells, 2019 - mdpi.com
Cannabidiol (CBD), a natural phytocannabinoid without psychoactive effect, is a well-known
anti-inflammatory and antioxidant compound. The possibility of its use in cytoprotection of …

Lipid oxidation derived aldehydes and oxysterols between health and disease

B Sottero, G Leonarduzzi, G Testa… - European journal of …, 2019 - Wiley Online Library
Non‐enzymatic and enzymatic oxidation of lipids has long been a primary issue in human
pathophysiology, with special emphasis on diet‐and nutrition‐related aspects. While there is …

Ferroptosis promotes cyst growth in autosomal dominant polycystic kidney disease mouse models

X Zhang, LX Li, H Ding, VE Torres… - Journal of the American …, 2021 - journals.lww.com
Background Autosomal dominant polycystic kidney disease (ADPKD), the most common
inherited kidney disease, is regulated by different forms of cell death, including apoptosis …