Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …

c-Jun N-terminal kinases (JNKs), also referred to as stress-activated kinases (SAPKs), were
initially characterized by their activation in response to cell stress such as UV irradiation …

Protein aggregation is a hallmark of multiple human pathologies. Autophagy selectively
degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive …

Neurofibrillary tangles (NFTs) in Alzheimer disease and related tauopathies are composed
of insoluble hyperphosphorylated Tau protein, but the mechanisms underlying the …

Neurofibrillary tangles composed of hyperphosphorylated, aggregated tau are a common
pathological feature of tauopathies, including Alzheimer's disease. Abnormal …

The microtubule-associated protein tau, abundant in neurons, has gained notoriety due to
the fact that it is deposited in cells as fibrillar lesions in numerous neurodegenerative …

Aggregation of highly phosphorylated tau into aggregated forms such as filaments and
neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer's disease …

Abstract Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of
Alzheimer's disease (AD). GSK-3β is involved in the formation of paired helical filament …

The neuropathology associated with Alzheimer's disease (AD) is characterized by the
presence of extracellularly neuritic plaques, intracellularly neurofibrillary tangles and the …

Dual-color fluorescence cross-correlation spectroscopy (FCCS) is a promising technique for
quantifying protein-protein interactions,,,,. In this technique, two different fluorescent labels …